Advances in the Separation and Preparation of Proanthocyanidins with Different Degree of Polymerization

Proanthocyanidins are polyphenols with a variety of physiological activities. The activity of proanthocyanidins has a great correlation with the degree of polymerization. Exploring efficient ways of the classification of proanthocyanidins has been a research hotspot.This article introduces the overview of proanthocyanidins and its main classification steps. Also,this paper mainly reviews the separation and preparation of proanthocyanidins with different polymerization degrees in recent years from perspective of two types of methods which are liquid-solid chromatography and liquid-liquid chromatography,in order to provide theoretical basis and guidance for the better preparation of procyanidins with different polymerization degrees,so that the physiological activity of proanthocyanidins can be more fully exerted.