Research advances on metabolism and regulation of polymalic acid production by strains of Aureobasidium spp.

Poly ( malic acid) is a fully biodegradable polymer material with advantages of high water-solubility, biodegradability and non-immunogenicity, which has wide application prospects in biomedicine and biomaterials industries.The metabolic pathway, the key enzyme systemsand the regulation metabolismin the biosynthesis of polymalic acid were summarized in this review.And the research tendency of poly-malic acid biosynthesis metabolism was also proposed.