Abstract: To address the issues of low bioavailability, degradation during processing, and limited use in precision nutrition of anthocyanins (ACNs). ACNs nanoparticles using ACNs as the core, soybean lecithin constructed-Liposome (Lipo), and Gum Arabic (GA) as the carrier were prepared in this study, namely Liposome/Gum Arabic-anthocyanins (Lipo/GA-ACNs) nanoparticles. In this study, nanoparticles of ACNs with ACNs as the core and liposomes (Lipo) constructed using soy lecithin and gum arabic (GA) as carriers, namely liposome/gum arabic-anthocyanins (Lipo/GA-ACNs) nanoparticles, were prepared. Environmental factors and in vitro simulated digestion on the stability of Lipo/GA-ACNs nanoparticles with various formulations were investigated. Additionally, the in vitro lipid-lowering activity of Lipo/GA-ACNs nanoparticles after digestion was examined. Results showed that Lipo/GA-ACNs nanoparticles had good stability under simulated thermal processing and different ion environments. When the ACNs to GA mass ratio was 1:10, the Lipo/GA-ACNs nanoparticles inhibited lipid droplet accumulation and reactive oxygen species accumulation in HepG-2 cells 3.8% and 1.99% more effectively than ACNs after simulated digestion. This study concluded that Lipo/1.0GA was a promising oral delivery system to deliver ACNs and achieve liver lipid-lowering, with the potential to be developed into functional foods with precision nutritional properties.