Abstract: Constructing the first-class undergraduate specialty, deepening curriculum reform, incorporating innovation and entrepreneurship education throughout the entire talent development process, and consistently enhancing the standard of innovation and entrepreneurship education are crucial approaches to fostering scientific and technological aptitude among college students. This study, according to the nature and characteristics of the course "Comprehensive Utilization of Grain and Oil Processing By-Products", focusing on the objectives of course teaching, under the guidance of the concept of innovation and entrepreneurship education, aims to explore the development and implementation of a practical case teaching method tailored to grain engineering students within the framework of the provincial first-class undergraduate specialty construction. By improving challenges such as lecture-based teaching, limited practical links, and one-dimensional assessment, a collaborative education platform of 'trinity' innovation and entrepreneurship teaching is proposed based on the construction idea of "classroom-experiment-practice". This platform emphasizes several improvement initiatives, such as incorporating industry case-inspired teaching, conducting classroom presentations, fostering the development of innovative experimental designs in small groups, cultivating the spirit of scientists, expanding the teaching of science and innovation competitions on the extracurricular activities, implementing multi-dimensional assessment methods, and establishing continuity mechanisms. Our goal is to establish a collaborative platform that nurtures innovation and entrepreneurship through the professional curriculum. Ultimately, this platform seeks to promote balanced development between professional knowledge and entrepreneurial skills, elevating the cultivation of innovative talents in grain engineering.