Abstract: To study the alleviating effect of different millet products on diarrhea caused by senna leaf in mice. Eighty-four KM mice were randomly divided into 7 groups: Normal control group, model group, positive control group, fermented millet group (6.16 g/kg), ferment millet bran group (2.05 g/kg), millet gruel oil group (10.27 g/kg), and millet bran porridge oil group (10.27 g/kg). Senna leaf was used to establish a diarrhea model in mice. After 7 days of modeling, except for the model group, the other groups were treated for 7 days. The diarrhea index, viscera index, serum inflammatory factors, secretory immunoglobulin A (SIgA) levels, and small intestine section observation were used to evaluate the effects of millet products on diarrhea mice. Compared with the model group, the weight of mice in the millet product group increased significantly on the 13th day (P<0.05), the diarrhea index was significantly decreased (P<0.05), the contents of serum inflammatory factors in ferment millet bran group, fermented millet group, and millet porridge oil group were significantly decreased (P<0.05), the content of secreted immunoglobulin A in intestinal mucosa was significantly increased (P<0.05), small intestine tissue section observation integrity was good. Fermented millet bran, fermented millet, and millet porridge oil in millet products could alleviate diarrhea induced by senna leaf in mice, but the therapeutic mechanism and the changes of intestinal flora in them remain to be further explored.