Abstract: Food Nutriology is one of the main course for students of Food Science in South China Agricultural University. The teaching group is devoted to reforming and innovation of teaching theory and practice, constantly improving the teaching resource, and applying the technical means of intelligent and information to teaching. The “learning-thinking-distinguishing-applying combination” teaching model is gradually formed. The course is awarded the national top-class undergraduate courses by the Ministry of Education in November 2020. The construction and development process of course, course positioning and objectives, construction of teaching group, course content and resources construction, teaching mode and characteristic innovation are introduced in this paper, to provide some useful references for advancing the construction and teaching reform of food science courses.