Abstract: With four layers of rice bran, soybean powder, purple rice powder, mushroom powder, corn powder, sweet potato powder and red date powder as the main raw materials, the linear programming method was used to design the layered rice bran meal replacement powder. Five kinds of layered rice bran meal replacement powder formulations were obtained under the main constraint that the dietary fiber content was not less than 13% of the total quality, and the price was not higher than six yuan/share. The optimal formulation was further determined by sensory evaluation, hydration characteristics and comparison of free radical clearance. Results showed that: The optimal formula contained rice bran 1# 30 g, rice bran 2# 30 g, rice bran 3# 98.68 g, rice bran 4# 34 g, soybean powder 22 g, purple rice powder 26 g, mushroom powder 14 g, corn powder 10 g, sweet potato powder 18 g, red jujube powder 30 g. The optimal formula had 16.03% dietary fiber content and sensory score of 80 points. At 25 and 100 ℃, the water absorption indexes of meal replacement powder were 1.07 and 1.19, water solubility were 68.46% and 71.22%, the expansion potential were 3.38 and 4.15. The free radical scavenging rates of DPPH and ABTS⁺ were 42.59% and 57.52%. The layered rice bran meal replacement powder had high dietary fiber content and strong antioxidant activity.