南极磷虾肽抗皮肤光老化作用的研究

于建伟; 杜芬; 陶宇; 付雪媛; 赵乐荣; 刘楚怡

doi:10.13386/j.issn1002-0306.2021030351

南极磷虾肽抗皮肤光老化作用的研究

Study on Anti-aging Activity of Peptide from Antarctic Krill

摘要

摘要: 本文以昆明小鼠为对象，研究南极磷虾肽对光老化皮肤损伤的保护作用。将昆明小鼠随机分为空白对照组、模型对照组、南极磷虾肽P-1组及P-2组，建立光老化小鼠模型，观察小鼠造模部位的表观特征并测定相关生化指标。结果显示，与模型对照组对比，P-1及P-2组小鼠皮肤较光滑，弹性大，红斑少，更接近正常组；P-1及P-2组可以极显著抑制光老化小鼠皮肤水分流失（P<0.01），糖胺聚糖（GAG）含量增高（P<0.01），胶原含量（P<0.05）及脂质含量（P<0.05）的降低；P-1及P-2组可以显著提高小鼠血清中总超氧化物歧化酶（T-SOD）、谷胱甘肽过氧化物酶（GSH-Px）、过氧化氢酶（CAT）的活力（P<0.05），显著降低丙二醛（MDA）的含量（P<0.05）。表明南极磷虾肽对小鼠光老化皮肤有显著的保护作用，为南极磷虾肽在化妆品领域的应用提供理论基础。

Abstract: The objective of this study was to explore the anti-aging effects of peptide from Antarctic krill on the skin of Kunming mice. The mice were randomly set as follows: Normal control group, model control group, group of Antarctic krill peptide (P-1), group of Antarctic krill peptide (P-2). Then characteristics and biochemical criterion analyzing were measured after mice were executed. The results showed that the skin of animals in P-1 and P-2 groups was similar to that of animals in model control group, showing elastic light wrinkled. Compared with the model group, the P-1 and P-2 groups significantly reduced water loss (P<0.01), significantly decreased levels of GAG, collagen breakdown of photoaging skin and lipid loss (P<0.05); the P-1 and P-2 groups significantly enhanced activity of T-SOD, CAT, GSH-Px and decreased levels of MDA in serum (P<0.05). This study showed that peptide from Antarctic Krill could protect skin against UV irradiation-induced photodamage. It provided a theoretical basis for the application of peptide from Antarctic Krill in the field of cosmetics.