Abstract: Food shelf life prediction is very important for space food and voyage food. Time-temperature indicator(TTI) is the key technology of food shelf life prediction. It can predict the change of food thermal nutrients by monitoring the food circulation temperature, and indicate the remaining shelf information of products, so as to reduce the loss of food and ensure food safety. This paper discusses the basic concept, principle, dynamic model and application of TTI. The research status of TTI based on physical type, chemical type, biological type, enzyme type and other different working principles are introduced. This paper summarizes the application of TTI in the storage and transportation monitoring of aquatic products, meat products, fruits and vegetables and fresh milk, as well as the commercial value and future development trend of TTI, in order to make contributions to the promotion of TTI technology application and the reduction of food waste.