Abstract: China's marine fish fishing and aquaculture industry has developed rapidly in recent years. Only a small part of the large amount of by-products produced during the processing of marine fish is used as feed, and most of them are discarded to cause environmental pollution. The internal organs of marine fish are rich in bioactive peptides, enzymes and lipids that can be effectively utilized, and it is necessary to develop and utilize them. This article reviews the bioactive peptides such as antioxidant peptides, anti-fatigue peptides, and anti-hypertensive peptides, visceral enzymes such as protease, superoxide dismutase, cholinesterase, and acid (alkali) in marine fish internal organs in recent years. Research progress on the extraction process and application of phosphatase, phospholipids, fatty acids and unsaponified lipids in lipids, and the future development and utilization of marine fish offal with high value suggestions are made to provide a reference for the high-value utilization of marine fish offal and to promote zero-waste high-value and high-quality processing of the marine fish industry.