Abstract: A method was developed for the simultaneous determination of 21 bisphenol and bisphenol derivatives in Baijiu contact plastic materials by ultra high performance liquid chromatography- high resolution mass spectrometry. The simulation solution was diluted 10 times with methanol. The compounds were separated on a C₁₈ chromatographic column with the gradient elution of water (contain 5 mmol/L ammonium) and methanol as mobile phase. The result showed that the limits of quantification were in the range of 2.5～500.0 µg/L, and the correlation coefficients (R²) of 21 target compounds were higher than 0.9965. The average spiked recoveries were in the range of 82.3%～106.4%, and the relative standard deviations (RSD) were in the range of 0.7%～5.2%. This method was simple, rapid, sensitive, accurate, and could be used for the monitoring of 21 bisphenol and bisphenol diglycidyl ethers in Baijiu and Baijiu contact plastic materials