Abstract: In order to verify the nutritional characteristics of hybrid sturgeon(Huso dauricus♀× Acipenser schrenckii♂)and contribute to the subsequent development and processing, samples of hybrid sturgeon from spring, summer, autumn and winter were collected to analyze and compare the differences of muscle basic nutrient composition, amino acid, fatty acid and mineral element. The results showed that the nutrient composition of cultured sturgeon had significantly difference in seasons. The fat content was higher in autumn and followed by winter, spring and summer (P<0.05), while the protein content was higher in winter and then decreased with seasons. Content of water and trace elements had negative correlation with fat content. The contents of essential amino acids (EAA), delicious amino acids (DAA) and total amino acids (TAA) were higher in spring, while the EAA/TAA was higher in autumn and DAA/TAA was higher in winter. Content of unsaturated fatty acids (UFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) had more advantage in summer and autumn than that of winter and spring (P<0.05), while no significant difference was observed on ration of unsaturated fatty acids in different seasons (P>0.05). Content of mineral elements were usually higher in spring and summer. The results showed that the nutritional composition of sturgeon were effected by seasonal variation significantly. It could become the theory foundation of sturgeon processing. The suitable sturgeon could be selected for different processing according to the results.