Abstract: Decreased bone mineral density may lead to osteoporosis,osteomalacia and other diseases. Prevention of bone mineral density decline is a practical problem faced by middle-aged and elderly people in China after entering the aging society. This paper is the first to make statistics on the compatibility of approved health food formulations for increasing bone mineral density in China in the past two decades. Taking calcium carbonate with the highest frequency of use and epimedium with the highest frequency of use of traditional Chinese medicine as examples,the compatibility rules of raw materials were found through data mining. Statistics show that calcium carbonate,glucosamine and chondroitin sulfate are often used in combination with calcium carbonate. Glucosamine,chondroitin sulfate,collagen and vitamin D are commonly used in the raw materials above the third order. In the products of epimedium as raw material,it is usually paired with soybean extract and bone tonic,etc. Chondroitin sulfate,soybean extract,casein phosphopeptide and vitamin D are commonly used as raw materials. In this paper,by looking for the formula compatibility rule,also from the perspective of supervision and management,the use basis of raw materials in the process of product development,registration and evaluation,the scientific basis of compatibility is analyzed,and finally,the use safety of raw materials in the use of health food should still be paid attention to.