Abstract: Perfluoroalkyl and polyfluoroalkyl substances(PFASs)are widely used in food contact materials as a class of synthetic chemicals. Increasing studies have shown that food can be used as a carrier for PFASs,allowing PFASs to enter the human body. The PFASs can be accumulated and distributed in the blood and organs,thus leading to a variety of health problems. In this paper,the research progress on the harm of PFASs and their contamination in food was reviewed. The pollution situation of PFASs in drinking water,milk and dairy products,meat,eggs,aquatic products,fruits and vegetables are summarized. The pathway in which PFASs entered food through the atmosphere,water,and soil is analyzed. Moreover,the hazards of PFASs to humans are summarized as follows:Leading to myocardial developmental toxicity,causing cell membrane lesions,and changing in human cholesterol levels. On this basis,the countermeasures for reducing PFASs in food are proposed. They are becoming urgent problems to be solved,including reducing the overuse of PFASs in food packaging,finding new substitutes for PFASs,and reducing the intake of PFASs through food.