Abstract: In order to develop and utilize flavonoids in Guanxi honey pomelo peel,ultrasonic assisted ethanol extraction method was used to extract flavonoids from pomelo peel of Guanxi honey,and single factor and response surface analysis method were used to explore the extraction process of flavonoids from pomelo peel of Guanxi honey. The optimal extraction conditions were optimized as follows:Liquid-solid ratio:30:1 mL/g,ethanol concentration:67%,ultrasonic frequency:163 W,ultrasonic temperature:35℃,and ultrasonic extraction time:50 min. Under these conditions,the predicted value of flavonoid extraction rate was 4.84%,and the measured value of flavonoid extraction rate was 4.90%,which proved that the theoretical predicted value of the model had a good fitting effect with the actual value. The ultrasonic assisted extraction process of flavonoids from Guanxi honey pommel peel was optimized,and providing a reference for the extraction and utilization of flavonoids from pomelo peel in Guanxi.