Abstract: Using Dendrobium officinale and Pueraria thomsonii as main materials while with corn starch,inulin,xylitol and mannitol as excipient,chewable tablets were prepared by ultrafine grinding,ingredients,wet granulation,drying,whole grain,pressing tablets and so on. The effect of ratio of main materials to excipient,proportion of auxiliary materials,ethanol concentration,adding amount of 60% ethanol and additive amount of magnesium stearate on the sensory quality of chewable tablet were observed. The formula of chewable tablets was optimized by L₁₆(4⁵)orthogonal experiment based on single experiment. The antioxidant activity of chewable tablets was evaluated by the model of DPPH· scavenging ability,ABTS⁺· scavenging ability and total antioxidant capacity.The results showed that the optimum technological formula were as follows:The ratio of main materials to excipient was 1:1.5 while the ratio of Dendrobium officinale to Pueraria thomsonii was 1:4,the proportion of auxiliary materials that was corn starch:inulin:xylitol:mannitol were 4:3:1:1,wetting agent of 60% ethanol 0.4 mL/g,magnesium stearate 1.5%,and under these conditions,sensory evaluation scores of the product was 93.7±0.03 score. The scavenging ability of chewable tablets water extract,chewable tablets alcohol extract and ascorbicacid V_C against DPPH· were(3.067±0.1095),(3.512±0.0945)and (0.06337±0.0286) mg/mL while against ABTS⁺· were (5.529±0.8175),(5.380±0.7915)and (0.2772±0.0345) mg/mL,respectively. The total antioxidant capacity of chewable tablets water extract,chewable tablets alcohol extract and ascorbic acid V_C with the concentration of 2 mg/mL were 0.258,0.188 and 0.494,respectively. Furthermore,all of the antioxidant activities mentioned above showed a dose relationship. The chewable tablets with Dendrobium officinale and Pueraria thomsonii would have a certain antioxidant activity and synergistic effect of Dendrobium officinale and Pueraria thomsonii in terms of antioxidant activity.