Abstract: Probiotics are a group of active microorganisms which have beneficial effects on host health when ingested in an appropriate amount. They play an important role in immune regulation by regulating the immune responses of dendritic cells(DC),monocytes,regulatory cells(Treg)and Th17 cells. Autoimmune diseases(AIDs)are diseases caused by the body's immune system,which cause cell destruction or tissue damage. For the treatment of AID,there is no radical medicine at present. Although traditional glucocorticoid and immunosuppressant can inhibit the rapid development of disease and improve the survival rate of patients,long-term use will cause a series of side effect. A large number of studies have found that probiotics can effectively alleviate autoimmune diseases. This paper summarizes the effects of probiotics on a variety of immune cells and the progress in autoimmune diseases.