Abstract: Taking Ulva pertusa polysaccharides(UP)as control,this paper studied the intervention effects of Ulva pertusa polysaccharides-zinc complex(UPZ)on glucose-lipid metabolism and antioxidant capacity of diabetic mice.The type Ⅰ diabetic model of mice was established by injecting streptozotocin(STZ).The experiment mice were divided randomly into 10 groups,including normal control,diabetic model,UP and UPZ with low,middle and high dose(polysaccharide:75,150,300 mg/kg BW/d,zinc sulfate:0.5,1,2 times of inorganic zinc group respectively),inorganic zinc(zinc sulfate,15 mg/kg BW/d Zn²⁺),metformin hydrochloride(300 mg/kg BW/d).All mice were subjected to intragastic administration for 4 weeks. Then the blood glucose,blood lipid and antioxidant capacity of liver of diabetic mice were determined. The results showed that UP and UPZ could significantly improve the glucose-lipid metabolism and antioxidant capacity of diabetic mice. The dose-effect relationship was obvious. Compared with model group,UP and UPZ could relieve the weight loss of diabetic mice,and reduce the liver and kidney indexes of diabetic mice. Both of them could significantly(P<0.05 or P<0.01)decrease fasting blood glucose,improve glucose tolerance,and lower cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C) levels,increase high density lipoprotein cholesterol(HDL-C) levels in serum of diabetic mice. Moreover,two samples could both improve the activities of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and catalase(CAT),reduce malondialdehyde(MDA)content in liver of diabetic mice. Furthermore,there was no significant difference(P>0.05) between the effects of high dose UPZ and metformin hydrochloride on organ injuries and glucose-lipid metabolism of diabetic mice. In addition,the effect of UPZ was stronger than UP at the same dose,and also stronger than zinc sulfate with the same zinc content.