Abstract: With the affirmation of the clinical effect of Acanthopanax senticosus and the continuous expansion of clinical application,domestic and foreign scholars have conducted in-depth research on the chemical composition,pharmacological effects and clinical application of Acanthopanax senticosus. In this paper,through the research progress on the chemical constituents of acanthopanax,flavonoids,lignans and polysaccharides in recent years,and the advancement of Acanthopanax senticosus on the pharmacological activities of cardiovascular and cerebrovascular system,nervous system,endocrine system,immune function regulation,anti-cancer,liver protection,anti-aging,anti-oxidation,anti-inflammatory,blood pressure lowering,anti-stress,it aims to provide an important reference for further development and utilization of plant resources for Acanthopanax senticosus.