Abstract: To study the regulation methods of immune function of cultured Mytilus edulis under cadmium(Cd²⁺)stress during temporary cultivation. Sodium selenite,selenized carrageenan,and carrageenan oligosaccharides were added to cultured seawater and the activity changes of antioxidant enzymes in visceral mass and hemolymph in cultured Mytilus edulis were evaluated. The results indicated that the different added additives showed different effects on the antioxidant enzyme activity and its variation trend.60 and 120 mg/L selenium carrageenan and carrageenan oligosaccharides were used to feed the cultured mussels during the period of 0~15 days. Compared with the cadmium(Cd²⁺)stressed Mytilus edulis and the normal Mytilus edulis,the selenium carrageenan and carrageenan oligosaccharides significantly improved the activities of total superoxide dismutase(T-SOD),glutathione peroxidase(GSH-PX),acid phosphatase(ACP),catalase(CAT),and phenoloxidase(PO). This study is of great significance in that the selenium carrageenan and carrageenan oligosaccharides can be used as temporary feeding nutrients of cultured Mytilus edulis to maintain and enhance the physiological activity of cultured mussels,and also provide some theoretical reference for the application of non-specific immunomodulatory techniques in the process of cultured mussels.