Abstract: The ultra-fine powder physical wall-breaking technology was used to break the wall of Eucommia ulmoides male flowers. Taking the wall-breaking rate of Eucommia ulmoides male flowers as an index,the effects of crushing time,water content of Eucommia ulmoides male flowers and feeding amount on the wall-breaking rate of Eucommia ulmoides male flowers were studied. The response surface curve method was used to optimize the conditions for breaking the wall of Eucommia ulmoides male flowers with ultra-fine powder and determine the leaching rate of flavonoids,aucubin,geniposide and chlorogenic acid before and after wall-breaking. Response surface methodology optimization results showed that the optimal wall-breaking conditions were as follows:Crushing time 8 min,feeding amount 100 g,water content of male flower 6%,wall-breaking rate up to 100%. Through microscopic observation of pollen liquid before and after ultra-fine powder wall-breaking treatment,it was shown that ultrafine powder had good wall-breaking effect,could promote the release of total flavonoids,chlorogenic acid and other contents,and improve the yield.