Abstract: Objective:To investigate the homology and drug resistance of Proteus mirabilis strains isolated from commercially available fresh meat in Zhongshan city and analyze the relationship between their genotypes and drug resistance phenotypes. Methods:71 P. mirabilis strains were classified by the enterobacterial repetitive intergenic consensus (ERIC) -PCR typing method and the acquired fingerprints were processed with Quantity One software. The Kirby-Bauer disk diffusion method was used for the antimicrobial resistance susceptibility testing, and the results were interpreted according to the standards established by the CLSI. Results:The similarity coefficients of 71 P. mirabilis strains were 0.64~1.00, and they were divided into 9 clusters bounded by 75%. In the 18 antibiotics tested, the strains had the highest rates of resistance to streptomycin and erythromycin, both reached 100%. The resistance rates to penicillin and ceftriaxone were the lowest, 16.90% and 11.27%, respectively. All strains were of multidrug resistance and were resistant to 6 drugs at least. Conclusion:71 P. mirabilis strains isolated from commercial available fresh meat had high similarity and serious drug resistance. There was no obvious correlation between their genotypes and resistance phenotypes.