Abstract: Chitosan is natural,non-toxic and degradable. It can effectively reduce lipid oxidation,water loss during the storage of aquatic products and inhibit the growth and reproduction of spoilage bacteria. It has a broad application prospect in the field of aquatic products preservation. In this paper,the mechanism of chitosan preservation was introduced firstly,and then the application of chitosan with other biological preservatives,the optimization of chitosan particle size and the combination of chitosan with other preservation methods were discussed. The effect and application analysis of the compound preservative containing chitosan on aquatic products were described in detail. The optimization and combination of several fencing factors could maintain the freshness and quality of aquatic products effectively. It provided reference for the quality control technology of aquatic products during cold chain transportation and storage.