Abstract: Eurotium cristatum is the predominant fungus of Fu-brick Tea in the fermentation process. As a probiotic,it can effectively regulate the metabolism of the human body,and has the effect of reducing fat,lowering blood pressure and regulating carbohydrate metabolism. E. cristatum has potential applications in the preservation of medicine and has been gradually paid attention to researchers. This study introduced the study status of pharmic,the biological activity and medical application of E. cristatum were reviewed in this paper. E. cristatum has the advantages of low requirement for culture conditions,easy to extract effective components,and is safe and non-toxic. E. cristatum has the biological activity of improving immunity,regulating intestinal flora,and lowering lipid,and it may play a new role in the fields of clinical antitumor,abdominal diarrhea,and weight loss.