Abstract: Red raspberry as the raw material,the polysaccharide of raspberry was extracted by compound enzyme method,then purified by DEAE-Sepharose Fast Flow ion exchange column chromatography and Sephadex column chromatography,and the molecular weight and monosaccharide composition of the polysaccharide were purified and the molecular weight and monosaccharide composition of RRP-I were determined by high performance liquid chromatography and gas chromatography. Their hypolipidemic effects were studied by animal experiments. The results showed that the molecular weight of RRP-I was 11220.1845 Da,and monosaccharide was composed of homogeneous polysaccharides composed of glucose. After the administration of RRP-I,the four indexes of TG,TC,LDL-C and HDL-C in the hyperlipidemic rats showed a significant trend. The serum levels of TG,TC and LDL-C in the low,middle and high dose groups of RRP-I showed a downward trend,while HDL-C showed an upward trend,showing a certain dose effect relationship,indicating that RRP-I had the effect of hyperlipidemic.