Abstract: In recent years, natural resources have attracted much attention due to their great potential to be explored in the discovery and development of new bioactive substances. Edible mushroom has become a major natural resources for it's rich in nutrition and larger output.This paper have reviewed the polyphenols that possess the function of anti-inflammatory, aiming at provide useful reference in further study in anti-inflammatory function of edible mushrooms and developing corresponding functional food of edible mushroom.