Abstract: To increase the value of Heraclum dissectum resource development and utilization,Heraclum dissectum was used as raw materia. The raw material was treated with different solvents(different concentrations of ethanol,methanol or ethyl acetate)to determine the proper extraction solutionl and the appropriate extraction solvent was determined by the inhibitory rate of α-glucosidase and α-amylase were chosen as indicator. And determined the optimal extraction conditions for the hypoglycemic functional component of Heraclum dissectum by single factor and response surface methods. The results showed that the optimum extraction solution was 80% ethanol,and the optimal extraction conditions were as follows:ultrasonic temperature was 49 ℃,ultrasonic time was 114.5 min and solid-liquid ratio was 1:15.3 g/mL. Under this condition,the inhibitory rate of α-glucosidase reached 69.52%±1.13% and the inhibitory rate of α-amylase reached 56.38%±0.96%. The IC₅₀ were 0.169 and 0.339 mg/mL respectively. Heraclum dissectum would be capable as source of α-glucosidase and α-amylase inhibitory for hypoglycemic function.