Abstract: Objective:To investigate effects of taurine on weight loss and lipid metabolism in hyperlipidemia rats. Methods:Based on the serum TC and body weight, Sprague-Dawley (SD) rats were randomly divided into four groups:control, model, taurine low dose and high dose groups. Rats in control group were fed with a normal diet, and those in other groups were fed with high-fat diet, and at the same time the rats in taurine group were given with taurine aqueous solution. After 12 weeks feeding, all rats were sacrificed for the measurement of serum TC, HDL-C, LDL-C, TG content, serum GSH-PX and SOD activities, fecal total bile acid content, liver TC, TG, FFA, reduced GSH, liver glycogen content and GSH-PX enzyme activity. Results:High dose taurine significantly reduced the body weight of rats with high-fat diet and both of two doses of taurine decreased epididymal fat pad index of rats. High dose taurine significantly decreased serum TC, LDL-C, liver FFA and glycogen in rats fed with high-fat diet, and the two doses of taurine had no effect on liver TC and TG, but both of them increased fecal total bile acid content notably. Both of two doses of taurine significantly increased serum GSH-PX and liver GSH-PX and reduced GSH. Conclusion:Taurine plays the role of weight-loss and lipid-reduction mainly by the way of promoting cholesterol conversion to bile acid and its excretion in feces, enhancing lipid metabolism, reducing liver FFA accumulation, improving the antioxidant capacity etc., however, the mechanism should be further studied.