Abstract: In order to protect the active ingredients of polyphenols in lotus solid waste from damage, enhance the stability of polyphenols. The embedding rate of polyphenols in lotus solid waste was optimized in the present study. Based on single factor, orthogonal test and response surface methodology, the best wall material formula for microencapsulation of polyphenols in lotus solid waste was optimized as follows:acacia:β-cyclodextrin was 3:1, the ratio of core to wall was 1:5, and the amount of monoglyceride was 0.10%. The optimum conditions for the spray drying were as follows:the content of the solid content was 16%, the feed rate was 280 mL/h, the inlet air temperature was 185℃ and the outlet temperature was 80℃. Under these conditions, the embedding rate of microcapsules was 94.12%±0.37%, and the embedding effect was better. It would provide a theoretical basis for the spray drying of polyphenols microencapsulation.