Abstract: The technological conditions of the spray-drying method for the preparation of microcapsule with the maltodextrin and gum acacia compound as wall material, Osmanthus essential oil as core, respectively. With microencapsulating rate as the main evaluating index, the processing technology for preparing Osmanthus essential oil micro-encapsulation by spray-drying was investigated and optimized by single-factor experiments and the response surface methodology. The result showed that the optimum processing parameters for the microencapsulation were as follows:The composition of the proper ratio of wall to material was the 1:2.5 (g:g) ratio of Arabic gum to malt dextrine and the mass ratio of core material to wall material was 1:6 (g:g), the homogeneous pressure was 40 MPa, the temperature of inlet wind for the spray-drying was 225℃ and the feed speed was 8 mL/min. Under the optimized technology, the predicted encapsulating rate of micro-encapsulation was 98.23%, the actual encapsulating rate was 97.67%, and the relative error was smaller than 1%. The microcapsule particles of Osmanthus oil had much better sensory and physical-chemical index and content of Osmanthus oil was 12.62%.