Abstract: Protein S-nitrosylation is one of post-translational modifications to protein that was closely related to nitric oxide. It is also a reversible oxidation-reduction reaction. Protein S-nitrosylation can affect the structure,activity and function of protein,and it was closely related to human health. In this paper,the concept,molecular mechanism and influencing factors of protein S-nitrosylation were reviewed. The effects of S-nitrosylation on postmortem aging and meat quality were studied. Calcium pathyway,the activity of protease-related enzymatic and postmortem glycolysis can be regulated by protein S-nitrosylation,and this can affect postmortem myofibrillar protein and meat quality furthermore.This can provide a theoretical foundation for the improving of meat quality from the perspective of protein S-nitrosylation.