Abstract: The hypoglycemic effects of low molecular weight collagen peptide intersecting Momordica charantia extracts were determined in mice diabetic model in vivo. The diabetic model mice were administrated collagen peptide and Momordia charantia extracts through intragastric administration and then the value of fasting glucose,body weight,organ mass and liver antioxidant capacity of the mice and given oral glucose tolerance test were measured. After the treatment of collagen peptide intersecting Momordica charantia extracts,the blood sugar value was decreased to 7.5~16.63 mmol/L,liver index and kidney index decreased to 44.98~56.17 mg/g,11.29~17.95 mg/g respectively. The spleen index increased to 2.71~3.52 mg/g,Area Under Curve reduced to 32.03~38.14 mmol/(min·L).Superoxide dismutase activity increased to 89.18~154.72 U/mg protein,and the content of MDA decreased to 1.66~3.00 nmol/mg protein. Compared with the model group,the bone collagen peptide of Epinephelussp intersecting Momordica charantia extracts of the middle dosage treatment group,and the skin collagen peptide of Oreochromis mossambicu intersecting Momordica charantia extracts of middle and high dosage treatment groups effect were remarkable. The blood sugar value at 28 days and AUC at 21 days decreased significantly,liver index and kidney index decreased,but the spleen index increased. The antioxidant ability of liver tissue increased. The results showed that the treatment of collagen peptide intersecting Momordica charantia extracts could significantly reduce the blood glucose value(p<0.05),and the blood glucose value related to the improvement of liver antioxidant capacity of diabetic mice model. Meanwhile,the treatment of collagen peptide intersecting Momordica charantia extracts could promote organ repair and improve the ability of autoimmunity.