Abstract: Totoaba macdonaldi-meat collagen peptides(TMCP)with molecular weight of 837 Da obtained from Mexican farmed Totoaba used combinative enzyme to investigate its effects on wound healing in mice. 40 healthy male ICR mice were underwent surgical full-thickness incision with a diameter of 8 mm and were divided into 4 groups,which were normal control group and 0.66,1.33,2.0 g/kg·bw TMCP groups. TMCP were orally administered by gavage to mice in TMCP group from post-operation,and the control mice were given vehicle only for 14 d. The healing of the wound were observed every 2 d. Necropsy was performed on postoperative 7 and 14 d. The wound tissues were excised for HE staining,Masson staining,hydroxyproline measurement and immunohistochemical analysis. According to results,TMCP-M and TMCP-H had highly significant positive effect on all indexes(p<0.01). TMCP-L could highly significantly increase the healing rate,collagen content,VEGF and bFGF expression on 14 d(p<0.01).TMCP groups could promote collagen producing and tissue remodeling. TMCP had potential to promote wound healing and could be used in high-quality oral healthy products,that would provide a theoretical basis for high-efficient utilization