Abstract: SangGe powder is a new anti-diabetic health food which is developing. Main active ingredients of it are polysaccharides and isoflavones. To study the best extractions process of mulberry leaves and pueraria by analysising the hypoglycemic active components of the medicinal material and the actual production. Verified the in vitro activity of the products. The optimum extraction techniques of mulberry leaves and pueraria were determined by orthogonal test,the yield of polysaccharides and puerarin and the rate of dry paste were used as the index of evaluation. The anti-diabetic activity was verified by measuring the α-glucosidase inhibitory activity of total polysaccharides from SangGe powder. The results showed that the best extraction process of mulberry leaves was 50 times of water at 80 ℃ for 3 times,and the extraction time was 1.0 h. The best extraction process of pueraria was 12 times of 70% ethanol,80 ℃ water baths for 2 times,and each time was 2 h. The yield of mulberry leaves was 3.86% and of puerarin was 26.30% after verification. Showed the extraction effect was better. The half-maximal inhibitory concentration(IC₅₀)value of Acarbose was 0.0648 g/L,the total polysaccharide of SangGe powder was 0.1862 g/L,the mulberry leaf polysaccharide was 0.3798 g/L. SangGe powder showed a good inhibitory effect on α-glucosidase,and the activity was significantly higher than that of mulberry leaf polysaccharide(p<0.01). The production process and in vitro activity study laid the foundation for the future development of SangGe powder.