Abstract: This paper aimed to prepare different degrees of substitution of CMKGM with KGM’s carboxymethyl modification.CMKGM and sodium alginate(SA)were complexed to prepare carboxymethyl glucomannan microcapsules via orifice method.Using bovine serum albumin as a model drug,the encapsulation efficiency and drug loading rate of microcapsules were determined. The tensile properties of microcapsules were determined by the method of GB/T1040.3-2006. The results showed that the optimal conditions of tensile property were the degree of substitution the(DS)of 75%,mixed proportion 3∶1(carboxymethyl konjac glucomannan∶sodium alginate),temperature 50 ℃,pH7.0.Good encapsulation and drug loading acquired by using BSA of 30.0 mg. The entrapment rate of blends in optimal conditions was 74%,drug loading efficiency was 76%,which has potential application value in biomedical field.