Abstract: To investigate the hepatoprotective effects of the different polarity fractions of extracts from the Fructus Akebiae on liver injury of CCl_4- treated mice. Different polarities crude extracts of Fructus Akebiae were obtained by using petroleum ether, ethyl acetate,butanol,and water.The liver injury models of mice were prepared with the intragastric administration of 0.3% CCl₄. The effects of different polarity fractions of Fructus Akebiae extracts on serum ALT and AST levels,SOD activities and MDA level in liver homogenate,and a pathological examination for the mice liver tissues were performed. The results indicated that the butanol extract and water extract of fructus akebiae could obviously reduce the activities of ALT and AST in CCl_4- treated^m ice,and increase the activities of SOD in hepatic tissue,and lower the content of MDA.The pathological section showed the butanol extract and water extract could improve the pathological changes of liver tissue. The results showed that butanol extract and water extract of Fructus Akebiae had noticeable protective effect against liver injury.