Abstract: Objective: It was evaluated that the antioxidant capacity of Lactobacillus plantarum KLDS 1.0386 strains in vitro and the antibiotic sensitivity of KLDS 1.0386 to 10 kinds of antibiotics. Methods: The antioxidant capabilities of KLDS 1.0386 in vitro were evaluated through survival efficacy under oxidative stress, DPPH free radical-scavenging activity, hydroxyl radicalscavenging activity, lipid peroxidation inhibition capacity, reducing activity, superoxide anion radical-scavenging activity, and Fe²⁺-chelating ability. The antibiotic sensitivity were evaluated through monobactams, carbopenems, glycopeptides, aminoglycosides, macrolides, lincosamides and amphenicols.Results: The antioxidant capabilities of cell suspension were better relative to cell-free extracts and fermented supernatant. KLDS 1.0386 was sensitive to ampicillin, penicillin, imipenem, gentamicin, erythromycin and tetracycline and was resistant to vancomycin, kanamycin, clindamycin and chloramphenicol.Concluton: L.plantarum KLDS 1.0386 had potential antioxidant capabilities and antibiotic resistance.