Abstract: A method of inductively coupled plasma optical emission spectrometry ( ICP-OES) and inductively coupled plasma mass spectrometry ( ICP-MS) was established to determine 46 elements in Siraitia grosvenorii.The detection limit of ICP-OES and ICP-MS were in the range of 0.68¹8.10 μg/L and 0.001 ⁰.093 μg/L, respectively.The precision of this method was in the range of 0.73% to 6.83%, and the recovery varied from 88.7% to 112.1%.The established method was used to determine the corresponding element content in the certified reference material of bush branch and leaf, which was in agreement with the certified values.The results showed that there were rich trace elements in Siraitia grosvenorii, 13 of which were more than2 mg/kg. The method was simple, rapid and accurate and suitable for the determination of multi-elements in Siraitia grosvenorii simultaneously.