Abstract: This review attempts to integrate the current knowledge about apigenin for potential to treat and prevent diabetes and obesity, also the mechanisms coupling signaling pathways manipulated by apigenin to improve β-cells function and insulin sensitive involving of the multitude of cell signaling pathways in pancreas, liver, skeletal muscle or adipose tissues were emphasized on. Apigenin shows great promise, which implies that apigenin derived from functional foods offer a novel and important approach for prevention of obesity and diabetes.The controversies and uncertainties in the pharmacology of apigenin that require resolution in future studies were also discussed.