Abstract: Four different solvents ( ethanol, methanol, acetone and water) were used for extracting the mycelium of Xylaria schweinitzii.The content of total phenolics and total flavonoids in the extracts from different solvents was analyzed and the scavenging capacity of DPPH radical scavenging capacity and total reducing power were determined.The results showed that the different solvent extracts had different antioxidant activity. At the concentration of each extract 2.5 mg/m L, the water extract showed the highest radical scavenging rate ( 91.8%) on DPPH, followed by 60% acetone extract and 70% ethanol extract, the scavenging rates were 89.6% and 83.6%, and the methanol extract showed the lowest scavenging rate which was ( 75.0%) on DPPH.The reduction ability of the different solvent extracts was in the order: water > 60% ethanol > 70% ethanol > 60%acetone > methanol.The highest content of total phenolics was found in water extract, but the highest content of total flavonoids was in methanol extract.In conclusion, the antioxidant activity of the aqueous extracts from the mycelium of Xylaria schweinitzii was significant, which probably has the potential to develop as a food antioxidant.