Abstract: Reactive oxygen species( ROS) production,their related enzymes,pathogenesis- related protein and the corresponding gene expression in potato tubers( Solanum tuberosum cv.Xindaping) treated with oligandrin were measured through in vivo tests.The results showed that 24 μg / m L oligandrin had the best effect,lesion diameter of potato tubers after treated with oligandrin was only 58.3% of the control.Further studies showed that H2O2 content and O-2·production rate of potato tubers treated with24 μg / m L of oligandrin peaked at 12 h,respectively,and incressed by 11.13% and 20.32% respectively compared to the control.In addition,the activities of peroxidase,polyphenol oxidase,superoxide dismutase,catalase,β-1,3- glucanase,chitinase and the corresponding gene expression in potato tubers were also enhanced by oligandrin. These findings suggested that oligandrin might induce potato tuber disease resistance through enhancing ROS metabolism and pathogenesis- related protein production.