Abstract: In this study,the weevers were selected as the raw material to research the effect of nisin combined with irradiation on the quality of fresh weever refrigeration. At first,the fresh weevers were treated with 0.3‰ Nisin,irradiation and 0.3‰ Nisin combined with irradiation,respectively and then storaged at 4 ℃.The total viable counts( TVC),2-thiobarbituric acid( TBA),total volatile base nitrogen( TVB-N),p H,surface hydrophobicity,drip loss value and whiteness were choosen as the evaluation indexes. The result showed that the treatment of 0.3‰ Nisin combined with irradiation can obviously delay the increase of the surface hydrophobicity,TVC,TVB-N and p H and then extend the shelf life.The TBA value was minimum in the group of 0.3‰ Nisin.The drip loss and the whiteness had the lowest values in the group of 2 k Gy and 4 k Gy irradiation,respectively. Based on the values of surface hydrophobicity,TVC,TVB-N and p H resualt,the treatment of 0.3‰ Nisin combined with 4 k Gy irradiation can extend 4 to 5 days of shelf life compared with blank group at 4 ℃.