Abstract: Tetracyclines is a kind of broad-spectrum antibiotics with four hydrocarbon rings derivation,which have complexation group and appropriate spatial configuration,could chelate with various metal ions to form the stable complexes,and the current study showes that the complexes have different bioactivity,chemical and physical property compared with Tetracyclines. The mechanism of the complexes Tetracyclines with metal ions,and the application and advances on different type of Tetracyclines metal-ion complex for chemical analytical detection,pharmaceutical discovery and environmental assessment were overviewed in this paper. And the development tendency of this complexes and its prospect were also anaylsed.