Abstract: Nutritional obese model was induced by feeding Wistar rats with high- fat diet. And then the model rats were treated with 200 mg /( kg·bw·d) of grape seed procyanidins by gavage for 6 weeks. Detected effect of procyanidin on obesity and activities of intestinal protease,amylase,lipase,alpha- glucosidase,beta- glucosidase.There was no significantly( p < 0.05) difference in weight and Lee's index between model group and ig group,while both the two groups were significantly different with normal group in weight and Lee's index. After the 6weeks' gavage of grape seed procyanidins,weight and Lee's index of ig group were significantly( p < 0.05) lower than model group.The activities of intestinal protease and lipase of ig group were significantly( p < 0.05) higher than that of model group and normal group,the amylase activity of ig group was significantly( p < 0.05) higher than normal group,but it was not significantly( p > 0.05) different with model group. There's no significant( p > 0.05)difference in intestinal α- glucosidase activity of three groups,while β- glucosidase activity of ig group were significantly( p < 0.05) lower compared with the model group and normal group. The results showed that200 mg /( kg·bw·d) of grape seed procyanidins could significantly inhibit obesity,and increase the activity of intestinal digestive enzyme to promote the absorption of nutrients,and reduce the activity of beta- glucosidase to lower blood glucose.