Abstract: Since the Caenorhabditis elegans genome displayes high homology( 40%) to human genome and its functions of neurons and neurotransmitters are also highly similar with those of humans,Caenorhabditis elegans have become an effective model of the neural mechanisms of disease.Researches of applications of transgenic Caenorhabditis elegans in Alzheimer 's disease were focused on and the applications of natural extracts in Alzheimer's disease in recent years were summarized.Also some monomers that were applied in transgenic Caenorhabditis elegans were summed up.