Abstract: The antioxidation and hepatic damage preventive effects of different vessels fermented Shuidouchi were investigated.The 4 g / kg Shuidouchi ethanol extracts treated mice could significantly( p < 0.05) reduce the liver weight,liver index,serum levels of ALT,AST,LDH,MDA,IL-6,IL-12,TNF-α,IFN- γ,and significant( p < 0.05) raise the SOD,GSH- Px serum levels compared to the hepatic damage group mice( CCl4 induced hepatic damage).By the RT- PCR assay,Shuidouchi could increase the Mn- SOD,Gu / Zn- SOD,CAT expressions and decrease i NOS,COX-2,IL- lβ,TNF-α expressions compared to the control mice. From these results,the glass vessel fermented Shuidouchi( GVFS) had the better hepatic damage preventive effects and antioxidation effects than ceramic vessel fermented Shuidouchi( CVFS) and plastic vessel fermented Shuidouchi( PVFS)( p < 0.05).