Abstract: Using the drying technology of hot air drying,microwave vacuum drying,explosion puffing drying,vacuum freeze-drying were used to prepare Flammulina velutipes root powder. The effects of different drying methods on powder physical properties of Flammulina velutipes root were studied.The results showed that the vacuum freeze-dried powder keep the best color,followed by microwave vacuum drying and explosion puffing drying.The Flammulina velutipes root powder prepared by vacuum freeze-drying and microwave vacuum drying particle size and the particle dispersion was significantly smaller than the hot air drying and explosion puffing drying,more uniform particle size. The Flammulina velutipes root powder prepared by hot air drying and explosion puffing drying were better flowability and compression molding. The Flammulina velutipes root powder prepared by microwave vacuum drying and vacuum freeze-drying had strong water holding capacity,and strongest oil holding capacity,up to 1.8 g/g. The Flammulina velutipes root powder prepared by hot air drying and explosion puffing drying had strong water solubility,and the microwave vacuum dried powder had worst water solubility.The Flammulina velutipes roots powder prepared by vacuum freeze-drying and microwave vacuum drying were suitable as a functional material added foods or adsorbed on the surface of the food.The Flammulina velutipes roots powder prepared by hot air drying and explosion puffing drying were suitable compressed tablets and extract the soluble component.