Abstract: Quinolones residue is currently one of important problems in animal- derived food safety.The detection of quinolones in a complex food matrix mainly relies on an effective pretreatment method and precision instruments.This paper summarized the research background and status of quinolones,and reviewed the research progress in China and other countries on pretreatment technologies,such as liquid- liquid extraction,solid- phase extraction,matrix solid- phase dispersion,Qu ECHERs,supercritical fluid extraction and immunoaffinity chromatography and detection methods,such as high performance liquid chromatography- tandem mass,high performance liquid chromatography,capillary electrophoresis and immunoassay,this review could provide reference of monitoring quinolones residues in food. The review suggests that SPE and Qu ECHERs are most promising pretreatment methods,and the development of mass- spectrometric technique and the miniaturization of instrument will be a development trend.