Abstract: Food peptidomics as an emerging field of food science and technology is gradually applied to the biological activity of the peptide preparation, purification, identification, and structure- activity relationship,involved the qualitative and quantitative aspects of bioactive peptides. Objective of this review was to highlight the increasing role of peptidomics as indispensable tool in the fields of production,purification,characterization,and structure-activity relationship of food-derived bioactive peptides,aimed to support extensive application reference of peptidomics in the food-derived peptides field.