Abstract: With the improvement of requirements of food safety and development of science and technology,much research and application of sterilization technology have recently been made. Traditional processing had been used as an effective technique for ensuing microbiological food safety in food industry. However,it also destroys nutrition and affects natural characteristics of the product. In order to keep the inherent quality of food to the greatest extent,some new sterilization technologies were emerging,such as ultra-high pressure processing,atmospheric non-equilibrium plasma,nanoparticles,acidic electrolyzed water and bacteriophages sterilization.The principle and their application in food industry were discussed in detail and this article also expected the development foreground of them,in order to provide reference information for application and development of these technologies and guarantee for food quality and security.